13th HBV CURE ANRS MIE WORKSHOP

Program

Wednesday, 25th March

10:00 - Welcome coffee

Joint opening and closing statements for RNH / HBV Cure Workshop

Yazdan Yazdanpanah, Éloi Verrier & Fabien Zoulim

Young investigator session

Chairs: Jean-Michel Pawlotsky and Éloi Verrier

HBV cure and RNH joint session

Keynote lecture

What are the knowledge gaps to cure HBV and HDV infections?
Massimo Levrero, Lyon

12:45 - Lunch break

Best Young Researcher Presentation Award

Viral genome persistence

Chairs: Christine Neuveut and Guillaume Giraud

Viral chromatin: the role of nucleosome occupancy in cccDNA transcription
Robert Schwartz, New York

Mappping the hepatic hepatitis B transcriptome and design
of single-cell tissue transcriptomics
Jane McKeating, Oxford

Immunological determinants of viral persistence

Chairs: Pierre Tonnerre and Hélène Strick-Marchand

Beyond exhaustion: T cell adaptation in chronic HBV infection

Maike Hofmann, Freiburg 

Tracking B cell immunity before functional cure: Insights from NA withdrawal and spontaneous HBsAg loss cohorts
Lucy Cooper, London 

Coffee break

The liver reservoir of infection

Chairs: Andres Roca and David Durantel

Spatial single-cell omics: new insights into liver diseases.
Bertram Bengsch, Freiburg 

Single-cell landscape of the myeloid cell adaptations during liver fibrosis
Moritz Peiseler, Berlin 

Heterogeneity of HBV/HDV and immune response distribution in the liver
Maëlle Locatelli 

Conclusions

Thursday, 26th March

8:00 - Welcome coffee

Novel therapies – Translational studies

Chairs: Patrick Soussan and Barbara Testoni

Induction of HBV-specific immune responses in immunocompetent humanized mice
Hélène Strick-Marchand, Paris 

Development of novel therapeutic vaccine candidates
Anna Kosinska, Munich 

Gene and epigenome editing of HBV
Anuj Kumar & Fabien Zoulim, Lyon 

New approach to target HDV with antisense oligonucleotides
Julie Lucifora, Lyon 

Coffee break

Cohort studies

Chairs: Vincent Thibault and Lucia Parlati

Hepatocellular carcinoma risk in a real-life cohort of chronic hepatitis B
Marc Bourlière, Marseille 

Immune profiling of patients with CHB and CHD
Upkar Gill, London 

Artificial intelligence in cohort studies and clinical trials for CHB and CHD
Anders Boyd, Bern 

Novel therapies – Progress in clinical development

Chairs: Vincent Leroy and Hélène Fontaine

Treatment endpoints to guide clinical development of novel therapies
Jordan Feld, Toronto 

Advances in RNA interference development
Man-Fung Yuen, Hong Kong 

An update on Bulevirtide and novel treatments for CHD
Elisabetta Degasperi, Milan 

12:55 - Farewell and buffet lunch

13th HBV CURE ANRS MIE WORKSHOP

Program

Wednesday, 25th March

10:00 - Welcome coffee

Joint opening and closing statements for RNH / HBV Cure Workshop

Yazdan Yazdanpanah, Éloi Verrier & Fabien Zoulim

Young investigator session

Chairs: Jean-Michel Pawlotsky and Éloi Verrier

HBV cure and RNH joint session

Keynote lecture

Chairs : Raymond Schinazi and Fabien Zoulim

What are the knowledge gaps to cure HBV and HDV infections ?
Massimo Levrero, Lyon

12:45 - Lunch break

Best Young Researcher Presentation Award

Viral genome persistence

Chairs: Christine Neuveut and Guillaume Giraud

Viral chromatin: the role of nucleosome occupancy in cccDNA transcription
Robert Schwartz, New York 

Mapping the hepatic hepatitis B transcriptome and design
of single-cell tissue transcriptomics
Jane McKeating, Oxford 

Immunological determinants of viral persistence

Chairs: Pierre Tonnerre and Hélène Strick-Marchand

Beyond exhaustion: T cell adaptation in chronic HBV infection

Maike Hofmann, Freiburg 

Tracking B cell immunity before functional cure: Insights from NA withdrawal and spontaneous HBsAg loss cohorts

Lucy Cooper, London 

Coffee break

The liver reservoir of infection

Chairs: Andres Roca and David Durantel

Spatial single-cell omics: new insights into liver diseases.
Bertram Bengsch, Freiburg 

Single-cell landscape of the myeloid cell adaptations during liver fibrosis
Moritz Peiseler, Berlin 

Heterogeneity of HBV/HDV and immune response distribution in the liver
Maëlle Locatelli, Barcelona 

Conclusions

Thursday, 26th March

08:00 - Welcome coffee

Novel therapies – Translational studies

Chairs: Patrick Soussan and Barbara Testoni

Induction of HBV-specific immune responses in immunocompetent humanized mice
Hélène Strick-Marchand, Paris 

Development of novel therapeutic vaccine candidates
Anna Kosinska, Munich 

Gene and epigenome editing of HBV
Anuj Kumar & Fabien Zoulim, Lyon 

New approach to target HDV with antisense oligonucleotides
Julie Lucifora, Lyon 

Coffee break

Cohort studies

Chairs: Vincent Thibault and Lucia Parlati

Hepatocellular carcinoma risk in a real-life cohort of chronic hepatitis B
Marc Bourlière, Marseille 

Immune profiling of patients with CHB and CHD
Upkar Gill, London 

Artificial intelligence in cohort studies and clinical trials for CHB and CHD
Anders Boyd, Bern 

Novel therapies – Progress in clinical development

Chairs: Vincent Leroy and Hélène Fontaine

Treatment endpoints to guide clinical development of novel therapies
Jordan Feld, Toronto 

Advances in RNA interference development
Man-Fung Yuen, Hong Kong 

An update on Bulevirtide and novel treatments for CHD
Elisabetta Degasperi, Milan 

12:55 - Farewell and buffet lunch