13th HBV CURE ANRS MIE WORKSHOP

Program

Wednesday, 25th March

10:00 - Welcome coffee

Joint opening and closing statements for RNH / HBV Cure Workshop

Yazdan Yazdanpanah, Éloi Verrier & Fabien Zoulim

Young investigator session

Chairs: Jean-Michel Pawlotsky and Éloi Verrier

HBV cure and RNH joint session

Keynote lecture: (20’ + 10 questions)

What are the knowledge gaps to cure HBV and HDV infections?
Massimo Levrero, Lyon

12:45 - Lunch break

Best Young Researcher Presentation Award

Viral genome persistence

Chairs: Christine Neuveut and Guillaume Giraud

Viral chromatin: the role of nucleosome occupancy in cccDNA transcription
Robert Schwartz, New York (20’ + 5’)

Episomal and integrated hepatitis B transcriptome mapping in the liver of CHB patients
Jane McKeating, Oxford (20’ + 5’)

Viral genome persistence

Chairs: Pierre Tonnerre and Hélène Strick-Marchand

HBV specific T cell modulation
Maike Hofmann, Freiburg (20’ + 5’)

HBV specific B cell responses
Lucy Cooper, London (20’ + 5’)

20' - Coffee break

The liver reservoir of infection

Chairs: Andres Roca and David Durantel

Spatial single-cell omics: new insights into liver diseases.
Bertram Bengsch, Freiburg (20′ + 5′)

Single-cell landscape of the myeloid cell adaptations during liver fibrosis
Moritz Peiseler, Berlin (20′ + 5′)

Heterogeneity of HBV/HDV and immune response distribution in the liver
Maëlle Locatelli (20′ + 5′)

Conclusions

Thursday, 26th March

8:00 - Welcome coffee

Novel therapies – Translational studies

Chairs: Patrick Soussan and Barbara Testoni

Induction of HBV-specific immune responses in immunocompetent humanized mice
Hélène Strick-Marchand, Paris (20′ + 5′)

Development of novel therapeutic vaccine candidates
Anna Kosinska, Munich (20′ + 5′)

Gene and epigenome editing of HBV
Anuj Kumar & Fabien Zoulim, Lyon (20′ + 5′)

New approach to target HDV with antisense oligonucleotides
Julie Lucifora, Lyon (20′ + 5′)

15' - Coffee break

Cohort studies

Chairs: Vincent Thibault and Lucia Parlati

Hepatocellular carcinoma risk in a real-life cohort of chronic hepatitis B
Marc Bourlière, Marseille (20′ + 5′)

Immune profiling of patients with CHB and CHD
Upkar Gill, London (20′ + 5′)

Artificial intelligence in cohort studies and clinical trials for CHB and CHD
Anders Boyd, Bern (20′ + 5′)

Novel therapies – Progress in clinical development

Chairs: Vincent Leroy and Hélène Fontaine

Treatment endpoints to guide clinical development of novel therapies
Jordan Feld, Toronto (20′ + 5′)

Advances in RNA interference development
Man-Fung Yuen, Hong Kong (20′ + 5′)

An update on Bulevirtide and novel treatments for CHD
Elisabetta Degespari, Milan (20′ + 5′)

12:55 - Farewell and buffet lunch

13th HBV CURE ANRS MIE WORKSHOP

Program

Wednesday, 25th March

10:00 - Welcome coffee

Joint opening and closing statements for RNH / HBV Cure Workshop

Yazdan Yazdanpanah, Éloi Verrier & Fabien Zoulim

Young investigator session

Chairs: Jean-Michel Pawlotsky and Éloi Verrier

HBV cure and RNH joint session

Keynote lecture: (20’ + 10 questions)

What are the knowledge gaps to cure HBV and HDV infections?
Massimo Levrero, Lyon

12:45 - Lunch break

Best Young Researcher Presentation Award

Viral genome persistence

Chairs: Christine Neuveut and Guillaume Giraud

Viral chromatin: the role of nucleosome occupancy in cccDNA transcription
Robert Schwartz, New York (20’ + 5’)

Episomal and integrated hepatitis B transcriptome mapping in the liver of CHB patients
Jane McKeating, Oxford (20’ + 5’)

Viral genome persistence

Chairs: Pierre Tonnerre and Hélène Strick-Marchand

Beyond exhaustion : T cell adaptation in chronic HVB infection
Maike Hofmann, Freiburg (20’ + 5’)

Distinct B cell phenotypes in chronic Hepatitis B precede spontaneous HBsAg clearance
Lucy Cooper, London (20’ + 5’)

20' - Coffee break

The liver reservoir of infection

Chairs: Andres Roca and David Durantel

Spatial single-cell omics: new insights into liver diseases.
Bertram Bengsch, Freiburg (20′ + 5′)

Single-cell landscape of the myeloid cell adaptations during liver fibrosis
Moritz Peiseler, Berlin (20′ + 5′)

Heterogeneity of HBV/HDV and immune response distribution in the liver
Maëlle Locatelli, Barcelona (20′ + 5′)

Conclusions

Thursday, 26th March

08:00 - Welcome coffee

Novel therapies – Translational studies

Chairs: Patrick Soussan and Barbara Testoni

Induction of HBV-specific immune responses in immunocompetent humanized mice
Hélène Strick-Marchand, Paris (20′ + 5′)

Development of novel therapeutic vaccine candidates
Anna Kosinska, Munich (20′ + 5′)

Gene and epigenome editing of HBV
Anuj Kumar & Fabien Zoulim, Lyon (20′ + 5′)

New approach to target HDV with antisense oligonucleotides
Julie Lucifora, Lyon (20′ + 5′)

15' - Coffee break

Cohort studies

Chairs: Vincent Thibault and Lucia Parlati

Hepatocellular carcinoma risk in a real-life cohort of chronic hepatitis B
Marc Bourlière, Marseille (20′ + 5′)

Immune profiling of patients with CHB and CHD
Upkar Gill, London (20′ + 5′)

Artificial intelligence in cohort studies and clinical trials for CHB and CHD
Anders Boyd, Bern (20′ + 5′)

Novel therapies – Progress in clinical development

Chairs: Vincent Leroy and Hélène Fontaine

Treatment endpoints to guide clinical development of novel therapies
Jordan Feld, Toronto (20′ + 5′)

Advances in RNA interference development
Man-Fung Yuen, Hong Kong (20′ + 5′)

An update on Bulevirtide and novel treatments for CHD
Elisabetta Degespari, Milan (20′ + 5′)

12:55 - Farewell and buffet lunch